Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis

摘要: The present invention describes compositions and methods for treating, preventing improving the appearance of skin, particularly, preventing, ameliorating, reducing and/or eliminating fine lines wrinkles wherein include limonoid constituents which inhibit acetylcholine release at neuromuscular junctions skeletal muscle so as to relax muscles involved with wrinkling, folding creasing e.g., facial movement expression. limonoids preferably plant alkaloids toosendanin azadirachtin. compositions, also are used treat hyperhidrosis, applied or delivered by directed means a site in need thereof.