Gold nanoparticles obtained by aqueous digestive ripening: Their application as X-ray contrast agents.
作者： Alessandro Silvestri , Laura Polito , Giacomo Bellani , Vanessa Zambelli , Ravindra P. Jumde
DOI: 10.1016/J.JCIS.2014.10.025
关键词: Digestive ripening 、 X-ray 、 In vivo 、 Nanotechnology 、 Chemical engineering 、 Aqueous solution 、 Surface modification 、 Metal 、 Chemistry 、 Nanoparticle 、 Colloidal gold
摘要: Abstract A preparative protocol to synthesize large quantities of size-controlled gold nanoparticles (Au NPs), stabilized by CH 3 O-PEG 5000 -SH (PEG-SH) in aqueous medium, is reported. The combination metal vapor synthesis (MVS) technique with digestive ripening process allowed obtain PEGylated Au NPs mean core particle size 3.8 nm and hydrodynamic diameters centered at 8.0 nm which were effectively used as computed tomography (CT) contrast agents for vivo experiments on mice. surface functionalization together the small engineered permitted their efficient renal clearance, still retaining a prolonged blood circulation stealth capability.
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