Pregnancy in IgA Nephropathy, Reflux Nephropathy, and Focal Glomerular Sclerosis

摘要: Fetal outcome was retrospectively studied in 217 pregnancies observed during the past two decades 93 patients, 34 suffering from IgA nephropathy (IgAGN, 69 pregnancies), 53 reflux (RN, 137 and six focal glomerular sclerosis (FGS, 10 pregnancies). Overall incidence of live births 175 (81%). loss, corrected for induced abortions, 66 (15%) IgAGN ,18 129 (14%) RN, 2 FGS. Renal failure hypertension preexisting prior to conception or developing early pregnancy were most important factors associated with unsuccessful fetal whereas urinary tract infection had limited effects RN patients. Influence on course maternal renal disease evaluated same groups An abnormally rapid deterioration function three women one patients (with an additional case among 46 further female patients) but none FGS group. All five experiencing functional a serum creatinine (SCr) level ≥200/μmol/L (2.3 mg/dL) at conception. Hypertension highly predictive recurrence subsequent remote development permanent We conclude that when is preserved, usually successful no deleterious are be expected IgAN, probably Conceiving SCr > 200 μmol/L mg/dL), however, increased risk loss high function.