p53 Superfamily proteins in marine bivalve cancer and stress biology.

摘要: Abstract The human p53 tumour suppressor protein is inactivated in many cancers and also a major player apoptotic responses to cellular stress. the two other members of this family (p63, p73) are encoded by distinct genes their functions have been extensively documented for humans some vertebrates. structure relative expression levels superfamily reported most invertebrate taxa. homologous proteins investigated only few invertebrates (specifically, flies, nematodes recently sea anemone). These studies classical model organisms all suggest that gene originally evolved mediate apoptosis damaged germ cells or protect from genotoxic Here, we correlated data number molluscan sequencing projects provide framework understanding signalling pathways marine bivalve cancer stress biology. (a) identified p63/73-like soft shell clam ( Mya arenaria ), blue mussel Mytilus edulis ) Northern European squid Loligo forbesi identical core sequences may be splice variants single gene, while molluscs more expressing different members; (b) transcriptional activation domains (TADs) 67–69% conserved with p53, those ecdysozoan, cnidarian, placozoan choanozoan eukaryotes ≤33% conserved; (c) Mdm2 binding site domain 100% sequenced (e.g. , Crassostrea Spisula but not present non-deuterostome invertebrates; (d) an homologue has cloned trossulus ; (e) homologues both upstream regulatory target exist genomes (missing ARF, CIP1 BH3 proteins) (f) demonstrably involved haemocyte germinoma cancers. We usually do know enough about molecular biology address mechanisms characterize particular diseases. Understanding basis naturally occurring diseases bivalves virtually unexplored aspect toxicoproteomics genomics related drug discovery. Additionally, increases coastal development concomitant aquatic pollutants driven interest developing models appropriate evaluating potential hazardous compounds conditions found environment. Data reviewed study coupled recent developments our superfamily. Taken together, they structurally functionally highly so far outside higher vertebrates chordates. Marine relevant best understood currently available experimental biomedical environmental researchers.