Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients.
作者： Lei Cai , Guomei Tang , Lishan Chen , Bosheng Zhang , Sanduo Jiang
DOI: 10.1097/00001756-200506210-00028
关键词: Allele frequency 、 Polymorphism (computer science) 、 Disease 、 Gene 、 Amyloid precursor protein secretase 、 Apolipoprotein E 、 Allele 、 Genetics 、 Traditional medicine 、 Genotype 、 Medicine
摘要: We investigated insertion (Ins)/deletion(Del) polymorphism in alpha-2-macroglobulin (A2M), G/C variant the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and apolipoprotein E (APOE) gene epsilon2/epsilon3/epsilon4 387 Chinese Han ethnic patients with Alzheimer's disease healthy study participants. After stratification for APOEepsilon4 status, only BACE1-G allele was significantly associated disease. Through meta-analysis of Del or G by pooling Asian studies, appeared to increase risk developing combination-analysis data about A2M-I/D A2M-Ile1000Val variants, A2M suggested be
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