Chemokine gene expression influences metastasis and survival time of female dogs with mammary carcinoma

摘要: Chemokines are signaling proteins secreted by immune cells which regulate leukocyte trafficking. The aberrant expression of chemokines and their receptors neoplastic influences the behaviour many human cancers. This study evaluated gene-expression chemokines: CCL5, CXCL10, CXCL12 chemokine receptors: CXCR3, CXCR4, CXCR7, CCR4, CCR9 in 41 histologically-malignant, outcome-known, canine mammary tumours. These were selected as all previously shown to influence breast CCL5 significantly higher tumours subsequently metastasised than that did not metastasise (p < 0.05). Increased these was also correlated with shorter survival times dogs (CCL5: rs = -0.40, p 0.02, CXCL12: 0.03) while independently prognostic 0.026). A proportion expressed CXCR3 0.037), CXCR4 0.026), CXCR7 0.025) 0.039) 0.045) express receptors. Chemokine receptor has been disease outcome findings indicate altered suggesting a potential role them markers or therapeutic targets.