Treatment of polycystic diseases with an hdac6 inhibitor
作者： Nicholas F. LaRusso , Sergio A. Gradilone
DOI:
关键词: Endocrinology 、 HDAC6 、 Cyst 、 Polycystic liver disease 、 Internal medicine 、 Phosphorylation 、 Medicine 、 Pathogenesis 、 Cholangiocyte proliferation 、 Acetylation 、 Bile duct 、 Cancer research
摘要: An HDAC6-specific inhibitor (i.e., a compound of Formula I or II) is shown to reduce the pathogenesis associated with polycystic disease. Administration an attenuated many symptoms characteristic liver disease including cyst formation, growth and cholangiocyte proliferation. Treatment also increased amount bile duct acetylated tubulin β-catenin phosphorylation and/or acetylation while reducing synthesis. These results demonstrate that HDAC6 overexpressed in cystic cholangiocytes its pharmacological inhibition reduces proliferation growth.
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