作者: Lawrence J. Marnett , Philip J. Kingsley , Daniel J. Hermanson
DOI: 10.1016/B978-0-12-420126-2.00004-3
关键词: Arachidonic acid 、 Oxidative phosphorylation 、 Biochemistry 、 Prostaglandin 、 Cyclooxygenase 、 Chemistry 、 Ethanolamide 、 Receptor 、 Endocannabinoid system 、 Amino acid
摘要: Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid (AA) and AA-containing esters/amides. The latter include endocannabinoids (ECs), 2-arachidonoylglycerol (2-AG), arachidonoylethanolamide (AEA), several arachidonoylamino acids. principal products are analogs prostaglandins that contain a glycerol ester, ethanolamide, or amino acid. These compounds exert potent biological activities but act through currently uncharacterized receptors. Recent advances have provided analytical methods chemical tools with which to interrogate involvement COX-2-dependent EC in physiological pathophysiological responses. This has led discovery their pain, anxiety, adipocyte differentiation, inflammation. reviewed perspective for future is offered.