Distinct Target-Derived Signals Organize Formation, Maturation, and Maintenance of Motor Nerve Terminals
作者： Michael A. Fox , Joshua R. Sanes , Dorin-Bogdan Borza , Veraragavan P. Eswarakumar , Reinhard Fässler
DOI: 10.1016/J.CELL.2007.02.035
关键词: Myocyte 、 Motor nerve 、 Synaptogenesis 、 Neuromuscular junction 、 Synaptic vesicle 、 Biology 、 Laminin 、 Cell biology 、 Immunology 、 Subfamily 、 Fibroblast growth factor
摘要: Target-derived factors organize synaptogenesis by promoting differentiation of nerve terminals at synaptic sites. Several candidate organizing molecules have been identified based on their bioactivities in vitro, but little is known about roles vivo. Here, we show that three sets organizers act sequentially to pattern motor terminals: FGFs, beta2 laminins, and collagen alpha(IV) chains. FGFs the 7/10/22 subfamily broadly distributed IV chains (alpha1/2) promote clustering vesicles as form. laminins concentrated sites are dispensable for embryonic development required postnatal maturation. Synapse-specific (alpha3-6) accumulate only after synapses mature maintenance. Thus, multiple target-derived signals permit discrete control formation, maturation, maintenance presynaptic specializations.
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