Ablación posquirúrgica con radioyodo en pacientes con carcinoma diferenciado de tiroides de bajo riesgo

作者: Juan J. Díez , Enrique Grande , Pedro Iglesias

DOI: 10.1016/J.MEDCLI.2014.01.009

关键词: HumanitiesMedicine

摘要: Resumen La mayoria de los pacientes con carcinoma diferenciado tiroides presentan tumores bajo riesgo mortalidad y recidiva. El tratamiento estandar estos ha consistido en la tiroidectomia total o casi total, seguida ablacion restos tiroideos radioyodo (ARI). Aunque ARI aporta ventajas, las actuales guias clinicas no recomiendan forma universal, ya que se demostrado aumente supervivencia libre enfermedad reduzca riesgo. Los avances comprension del comportamiento biologico cancer han traducido clinica una aproximacion personalizada al paciente basada su particular recidiva mortalidad. evidencia actualmente disponible muestra esta indicada riesgo, especialmente carcinomas papilares menores 1 cm, sin extension extratiroidea, histologia desfavorable, compromiso ganglionar ni metastasis a distancia. seguimiento determinaciones tiroglobulina serica ecografias seriadas considera suficiente. evaluacion cuidadosa todos factores relevancia nos permitira mas realista cada concreto.

参考文章(56)
E Papini, L Pedrazzini, R Guglielmi, L Marzoli, A Baroli, Cancer recurrence in papillary thyroid microcarcinoma: a multivariate analysis on 231 patients with a 12-year follow-up Minerva Endocrinologica. ,vol. 38, pp. 269- 279 ,(2013)
R. Michael Tuttle, Robert I. Haddad, Douglas W. Ball, David Byrd, Paxton Dickson, Quan-Yang Duh, Hormoz Ehya, Megan Haymart, Carl Hoh, Jason P. Hunt, Andrei Iagaru, Fouad Kandeel, Peter Kopp, Dominick M. Lamonica, William M. Lydiatt, Judith McCaffrey, Jeffrey F. Moley, Lee Parks, Christopher D. Raeburn, John A. Ridge, Matthew D. Ringel, Randall P. Scheri, Jatin P. Shah, Steven I. Sherman, Cord Sturgeon, Steven G. Waguespack, Thomas N. Wang, Lori J. Wirth, Karin G. Hoffmann, Miranda Hughes, Thyroid Carcinoma, Version 2.2014 Journal of The National Comprehensive Cancer Network. ,vol. 12, pp. 1671- 1680 ,(2014) , 10.6004/JNCCN.2014.0169
Donald SA McLeod, Anna M Sawka, David S Cooper, Controversies in primary treatment of low-risk papillary thyroid cancer The Lancet. ,vol. 381, pp. 1046- 1057 ,(2013) , 10.1016/S0140-6736(12)62205-3
Antonis Valachis, Andreas Nearchou, High versus low radioiodine activity in patients with differentiated thyroid cancer: a meta-analysis. Acta Oncologica. ,vol. 52, pp. 1055- 1061 ,(2013) , 10.3109/0284186X.2012.742959
Anna M. Sawka, James D. Brierley, Richard W. Tsang, Lehana Thabane, Lorne Rotstein, Amiram Gafni, Sharon Straus, David P. Goldstein, An Updated Systematic Review and Commentary Examining the Effectiveness of Radioactive Iodine Remnant Ablation in Well-Differentiated Thyroid Cancer Endocrinology and Metabolism Clinics of North America. ,vol. 37, pp. 457- 480 ,(2008) , 10.1016/J.ECL.2008.02.007
Jacqueline Jonklaas, Nicholas J. Sarlis, Danielle Litofsky, Kenneth B. Ain, S. Thomas Bigos, James D. Brierley, David S. Cooper, Bryan R. Haugen, Paul W. Ladenson, James Magner, Jacob Robbins, Douglas S. Ross, Monica Skarulis, Harry R. Maxon, Steven I. Sherman, Outcomes of patients with differentiated thyroid carcinoma following initial therapy. Thyroid. ,vol. 16, pp. 1229- 1242 ,(2006) , 10.1089/THY.2006.16.1229
Pedro W.S. Rosário, Michelle A.R. Borges, Maristane M.A. Valadão, Flávio P.J. Vasconcelos, Leonardo L. Rezende, Eduardo L. Padrão, Álvaro L. Barroso, Saulo Purisch, Is adjuvant therapy useful in patients with papillary carcinoma smaller than 2 cm Thyroid. ,vol. 17, pp. 1225- 1228 ,(2007) , 10.1089/THY.2006.0254
Claire Schvartz, Franck Bonnetain, Sandrine Dabakuyo, Mélanie Gauthier, Adèle Cueff, Sandrine Fieffé, Jean-Marie Pochart, Inna Cochet, Elodie Crevisy, Audrey Dalac, Dimitri Papathanassiou, Michel Toubeau, Impact on overall survival of radioactive iodine in low-risk differentiated thyroid cancer patients. The Journal of Clinical Endocrinology and Metabolism. ,vol. 97, pp. 1526- 1535 ,(2012) , 10.1210/JC.2011-2512
Rosj Gallicchio, Sabrina Giacomobono, Daniela Capacchione, Anna Nardelli, Francesco Barbato, Antonio Nappi, Teresa Pellegrino, Giovanni Storto, Should patients with remnants from thyroid microcarcinoma really not be treated with iodine-131 ablation? Endocrine. ,vol. 44, pp. 426- 433 ,(2013) , 10.1007/S12020-013-9935-9