Production of dicarboxylic acids by improved mutant strains of yarrowia lipolytica
作者： Rémy Marchal , Marie-Thérèse Le Dall , Jean-Marc Nicaud
DOI:
关键词: Stereochemistry 、 Bioconversion 、 Mutant 、 Strain (chemistry) 、 Substrate (chemistry) 、 Materials science 、 Alkyl 、 Hydrocarbon 、 Organic chemistry 、 Carbon 、 Yarrowia
摘要: The invention concerns a method for producing dicarboxylic acids (DCA) with long hydrocarbon chains, also called diacids, which consists in culturing mutant strain of Yarrowia lipolytica obtained by mutagenesis directed and more particularly disrupted at least the POX2, POX3, POX4 POX5 genes encoding acyl-CoA oxydase, medium consisting essentially an energetic substrate including one carbon source nitrogen subjecting said to bioconversion selected among n-alkanes 10 atoms, fatty their alkyl esters natural oils.
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