Pharmacokinetics of Amikacin after a Single Intravenous Dose

摘要: Amikacin, an aminoglycoside antibiotic, has been used extensively in humans and other animals to treat infections produced by Gram-negative bacteria. The pharmacokinetics of amikacin studied foals, but because its high cost it not adult horses. present study was designed determine if a single intravenous dose (10 mg/kg) will reach therapeutic concentrations plasma horses (n=6) evaluate the concentration synovial, peritoneal, interstitial fluid with same dosage. Serum averaged 115.93 ± 8.254 μg/ml at three minutes, after 60 minutes mean 39.311 5.052 μg/ml. area under curve (AUC) 139.34 34.02 μg*h/ml; elimination half-life (t½β) 1.346 0.4 hours; total body clearance 1.251 0.281 ml/min/kg, mean residual time (MRT) 1.814 0.5 hours. serum for all below minimum detectable assay 24 hours. The maximum (Cmax) injection 19.78 7.14 21.44 4.39 synovial peritoneal fluid, respectively. achieve (Tmax) 65 12.24 115 fluid. infinite (AUC0-∞) 100.02 39.89 μg*h/ml 139.99 25.88 Amikacin reached Cmax 10.82 5.33 μg/ml, hours 3.316 1.69 μg/ml. Based on results pharmacokinetic analysis, appear that would be caused susceptible bacteria inhibitory (MIC) ≤8 Due individual variation, close drug monitoring is recommended.