Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection.

摘要: Asthma exacerbations are frequently linked to rhinovirus infections. However, the associated inflammatory pathways poorly understood, and treatment of is often unsatisfactory. In present study we investigated whether antiinflammatory with inhaled corticosteroids prevents any rhinovirus-induced worsening lower airway inflammation. To that end, selected 25 atopic patients mild asthma who underwent experimental 16 (RV16) infection, while receiving double-blind, placebo-controlled corticosteroid budesonide (800 microg twice a day) throughout period, starting 2 wk before infection. We assessed cell numbers in bronchial mucosa as obtained by biopsies d 6 after RV16 analyzed those relation cold symptoms, changes blood leukocyte counts, obstruction, hyperresponsiveness. colds induced an increase CD3(+) cells lamina propria (p = 0.03) tended decrease epithelial eosinophils 0.06) both groups whole. The T accumulation was positively symptoms. Budesonide pretreatment improved hyperresponsiveness 0.02) eosinophilic airways inflammation 0.04). Yet it did not significantly affect RV16-associated types. conclude infection itself induces only subtle asthma, which (or worsened) corticosteroids. latter finding keeping limited protection against acute exacerbations.