Increased STAT3 phosphorylation on CD27(+) B-cells from common variable immunodeficiency disease patients.
作者： Antonio Clemente , Jaume Pons , Nallibe Lanio , Vanesa Cunill , Guillem Frontera
DOI: 10.1016/J.CLIM.2015.09.004
关键词: Immune system 、 Cancer research 、 B-cell activating factor 、 Receptor 、 Common variable immunodeficiency 、 Phosphorylation 、 CD40 、 Cellular differentiation 、 Hyperphosphorylation 、 Molecular biology 、 Biology
摘要: Maturation and differentiation of B-cells are driven by T-cells' help through IL-21/STAT3 axis in GC centers or through extrafollicular pathways, in a T-independent manner. B-cell …
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