TRAP1 controls cell migration of cancer cells in metabolic stress conditions: Correlations with AKT/p70S6K pathways.

摘要: Abstract Cell motility is a highly dynamic phenomenon that essential to physiological processes such as morphogenesis, wound healing and immune response, but also involved in pathological conditions metastatic dissemination of cancers. The involvement the molecular chaperone TRAP1 regulation cell motility, although still controversial, has been recently investigated along with some well-characterized roles cancer survival drug resistance several tumour types. Among different functions, TRAP1-dependent protein synthesis seems be migratory behaviour cells and, interestingly, expression p70S6K, kinase responsible for translation initiation, playing role regulated by TRAP1. In this study, we demonstrate silencing enhances vitro compromises ability overcome stress conditions, effect mediated AKT/p70S6K pathway. fact: i) inhibition p70S6K activity specifically reduces migration knock-down cells; ii) nutrient deprivation affects thereby impairing only TRAP1-deficient iii) regulates both AKT at post-transcriptional level; modulates genes epithelial–mesenchymal transition. Notably, correlation between found vivo human colorectal tumours. These results provide new insights into cells, progression mechanisms.