Effects of Caloric Restriction on Aflatoxin B1 Metabolism and DNA Modification in Fischer 344 Rats

摘要: Laboratory animals maintained on a reduced calorie, but nutritionally adequate diet have extended life spans and lowered incidence of spontaneous chemically induced cancers compared to ad libitum-fed counterparts (Allaben et al., Chapter 4; Kritchevsky Klurfeld 1987). Results obtained from early studies, such as the pioneering work Tannenbaum (1942) effect caloric restriction (CR) mouse skin tumors by benzo(a)pyrene, numerous recent studies employing variety levels different carcinogens induce at tissue sites (Kritchevsky 1986; Sarkar al. 1982; Gross 1988; Lagopoulous Stadler 1987; Newberne Rogers 1986) demonstrate profound impact tumorigenesis. Although mechanisms underlying inhibitory CR carcinogenesis are still not clear, hypotheses been proposed which generally focus promotion stage (Pariza Boutwell 1984). Recent reports that alters xenobiotic metabolizing enzyme activities (Sachan Sachan Das Hasmi al Koizumi Leakey 1989a,b, see also this volume; Table 5.1), decreases 7,12-dimethylbenz(a)anthracene (DMBA) binding dermal DNA in mice (Pashko Schwartz 1983), inhibits indirect- direct-acting chemical rats (Pollard Luckert 1985; 5.2), reduces aflatoxin B1 (AFB1) hepatic (Pegram 1989) indicate addition cancer promotion, initiation can be significantly inhibited CR.