Drug targeting using thermally responsive polymers and local hyperthermia
作者： D.E. Meyer , B.C. Shin , G.A. Kong , M.W. Dewhirst , A. Chilkoti
DOI: 10.1016/S0168-3659(01)00319-4
关键词: Acrylamide 、 Targeted drug delivery 、 Polymer 、 Drug carrier 、 Drug delivery 、 Video microscopy 、 Chemistry 、 Biophysics 、 Lower critical solution temperature 、 Stereochemistry 、 Hyperthermia
摘要: We report a new thermal targeting method in which thermally responsive drug carrier selectively accumulates solid tumor that is maintained above physiological temperature by externally applied, focused hyperthermia. synthesized two polymers were designed to exhibit lower critical solution (LCST) transition slightly temperature: (1) genetically engineered elastin-like polypeptide (ELP) and (2) copolymer of N-isopropylacrylamide (NIPAAm) acrylamide (AAm). The delivery systemically injected polymer-rhodamine conjugates tumors was investigated vivo fluorescence video microscopy ovarian implanted dorsal skin fold window chambers nude mice, with without local When heated 42 degrees C, the accumulation ELP LCST 40 C approximately twofold greater than concentration same polymer not heated. Similar results also obtained for poly(NIPAAM-co-AAm), though enhanced this observed ELP. These suggest drugs can be achieved conjugation combined heating tumors.
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