Synthesis of imidazolium-terminated carbosilane dendrimers and dendrons and study of their interactions with a cell membrane model

摘要: Abstract A new family of imidazolium-terminated carbosilane dendrimers and dendrons was synthesized characterized as a nanotechnological alternative to current therapies. The aim this research the study interacting process nano-structures with cell membrane model (lecithin liposomes), final ambitious purpose use these for biomedical applications, e.g. anticancer drug. interactions occurring over time between dendrimers, at different generations (from G1 G3) concentrations (1 mM, 10 mM 20 mM), models were investigated using computer-aided analysis electron paramagnetic resonance (EPR) spectra selected spin probes, able enter liposome membrane, mimicking phospholipid behavior. EPR provided structural dynamical information on systems indicating that increase in generation concentration produced an increased perturbation structure. poorly interacted interaction almost independent dendrimer decreased time. Conversely, G3 showed significant variation respect concentration. fast kinetics internalization proposed low concentration, while accumulation surface slowed down process. cytotoxic effect verified by vitro screening selection tumor lines, parallel results.