Identification of a New Variable Sequence in the P1 Cytadhesin Gene of Mycoplasma pneumoniae: Evidence for the Generation of Antigenic Variation by DNA Recombination between Repetitive Sequences
作者： Tsuyoshi Kenri , Rie Taniguchi , Yuko Sasaki , Norio Okazaki , Mitsuo Narita
DOI: 10.1128/IAI.67.9.4557-4562.1999
关键词: Biology 、 Gene 、 Genome 、 Genetics 、 DNA 、 Antigenic variation 、 Gene cluster 、 Sequence analysis 、 Repeated sequence 、 Nucleic acid sequence
摘要: A Mycoplasma pneumoniae cytadhesin P1 gene with novel nucleotide sequence variation has been identified. Four clinical strains of M. were found to carry this type gene. This new is similar the known group II genes but possesses approximately 300 bp in RepMP2/3 region. The position variable region distant from previously reported regions differ between I and genes. Two sequences closely homologous within repetitive outside M129 genome. suggests that was generated by DNA recombination locus. finding supports hypothesis genome serve as a reservoir generate antigenic
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