The ICM research agenda on intensive care unit-acquired weakness

摘要: We present areas of uncertainty concerning intensive care unit-acquired weakness (ICUAW) and identify for future research. Age, pre-ICU functional cognitive state, concurrent illness, frailty, health trajectories impact outcomes should be assessed to stratify patients. In the ICU, early assessment limb diaphragm muscle strength function using nonvolitional tests may useful, but comparison with established methods global specific physical determination their reliability normal values would important advance these techniques. Serial measurements respiratory strength, systematic screening dysphagia, helpful clarify if how groups is independently associated outcome. ICUAW, delirium, sedatives analgesics interact each other, amplifying effects individual factor. Reduced mobility in patients hypoactive delirium needs investigations into dysfunction central peripheral nervous system motor pathways. Interventional nutritional studies include mass, as outcomes, prioritize elucidation mechanisms. At follow-up, ICU survivors suffer from prolonged wasting other impairments, well fatigue without demonstrable on examination. Further evaluate prevalence severity define its association psychiatric disorders, pain, impairment, axonal loss. Finally, methodological issues, including accounting baseline status, handling missing data, inclusion patient-centered outcome measures addressed studies.