Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice
作者： Masato Hosokawa , Tetsuaki Arai , Masami Masuda-Suzukake , Takashi Nonaka , Makiko Yamashita
DOI: 10.1371/JOURNAL.PONE.0052389
关键词: Molecular biology 、 Tauopathy 、 Methylene blue 、 Blot 、 In vivo 、 Programmed cell death 、 Phenothiazine 、 Genetically modified mouse 、 In vitro 、 Chemistry
摘要: In neurodegenerative disorders, abnormally hyperphosphorylated and aggregated tau accumulates intracellularly, a mechanism which is thought to induce neuronal cell death. Methylene blue, type of phenothiazine, has been reported inhibit aggregation in vitro. However, the effect methylene blue vivo remained unknown. Therefore, we examined whether suppresses abnormal accumulation using P301L transgenic mice. At 8 11 months age, these mice were orally administered for 5 months. Subsequent results Western blotting analysis revealed that this agent reduced detergent-insoluble phospho-tau. may have potential as drug candidate treatment tauopathy.
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