Vaginal LPS changed gene transcriptional regulation response to ischemic reperfusion and increased vulnerability of fetal brain hemorrhage

摘要: During pregnancy, both ischemic reperfusion and bacterial agent LPS are known risk factors for fetal brain damage. However, there is a lack of evidence to explain whether vaginal affects the fetus response reperfusion. Here we reported that was more than 2 folds higher vulnerability hemorrhage when mother mouse treated with LPS. As our previously reported, induces P53-dependent damage based on molecular mechanism: transcriptional pattern changed from HIF-1alpha-dependent immediately. In present work, only precondition, phosphorylation activated factor (ATF) at Thr71 appeared in Moreover, this completely blocked by pre-treatment P53 inhibitor, pifithrin-α. We concluded precondition trigged p53-dependent ATF2 reperfusion, which played an important role increasing fetus.