Acid–base dysregulation and chemosensory mechanisms in panic disorder: a translational update

摘要: Panic disorder (PD), a complex anxiety characterized by recurrent panic attacks, represents poorly understood psychiatric condition which is associated with significant morbidity and an increased risk of suicide attempts completed suicide. Recently however, neuroimaging provocation challenge studies have provided insights into the pathoetiology phenomena begun to elucidate potential neural mechanisms that may underlie attacks. In this regard, accumulating evidence suggests acidosis be contributing factor in induction panic. Challenge patients PD reveal attacks reliably provoked agents lead acid–base dysbalance such as CO2 inhalation sodium lactate infusion. Chemosensory translate pH panic-relevant fear, autonomic, respiratory responses are therefore high relevance understanding pathophysiology. Herein, we provide current update on clinical preclinical supporting how imbalance diverse chemosensory discuss future implications these findings.