The natural history of symptomatic androgen deficiency in men: onset, progression, and spontaneous remission.

摘要: OBJECTIVES: To describe the onset, progression, and remission of symptomatic androgen deficiency (SAD) using longitudinal data from Massachusetts Male Aging Study (MMAS). DESIGN: A prospective, population-based study men living in Boston, Massachusetts. Data were collected three waves: T1 (1987/89), T2 (1995/97), T3 (2002/04). Onset, defined terms transitions SAD status one wave to next. SETTING: In-person, in-home interviews. PARTICIPANTS: Seven hundred sixty-six community-dwelling aged 40 70 at baseline (T1) contributed 391 T3. MEASUREMENTS: was serum total free testosterone (T) levels symptoms associated with low circulating androgens. Total T sex hormone–binding globulin (SHBG) measured radioimmunoassay. Free calculated SHBG measurements. RESULTS: At or T3, likelihood markedly greater for subjects who had exhibited previous (odds ratio=3.8, 95% confidence interval=1.9–7.4), overall 55% experienced by next wave. The probability older age body mass index. Multivariate models demonstrated that least 50% most subpopulations. CONCLUSION: Over approximately 15 years follow-up, did not represent a stable health state. would remit exceeded it not, particularly among younger leaner men.