Latent Enhancers Activated by Stimulation in Differentiated Cells
作者： Renato Ostuni , Viviana Piccolo , Iros Barozzi , Sara Polletti , Alberto Termanini
DOI: 10.1016/J.CELL.2012.12.018
关键词: Enhancer RNAs 、 Enhancer 、 Stimulation 、 Cellular differentiation 、 Histone 、 Cell biology 、 Transcription factor 、 Histone code 、 Biology 、 Regulation of gene expression 、 Genetics
摘要: According to current models, once the cell has reached terminal differentiation, the enhancer repertoire is completely established and maintained by cooperatively acting lineage-specific transcription factors (TFs). TFs activated by extracellular stimuli operate within this predetermined repertoire, landing close to where master regulators are constitutively bound. Here, we describe latent enhancers, defined as regions of the genome that in terminally differentiated cells are unbound by TFs and lack the histone marks characteristic of …
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Charles Elkan, Timothy L. Bailey, Fitting a mixture model by expectation maximization to discover motifs in biopolymers. intelligent systems in molecular biology. ,vol. 2, pp. 28- 36 ,(1994)
Rasmus Siersbaek, Ronni Nielsen, Sam John, Myong-Hee Sung, Songjoon Baek, Anne Loft, Gordon L Hager, Susanne Mandrup, Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis The EMBO Journal. ,vol. 30, pp. 1459- 1472 ,(2011) , 10.1038/EMBOJ.2011.65
Sara Polletti, Betsabeh Khoramian Tusi, Heiko Muller, Jiannis Ragoussis, Chia-Lin Wei, Gioacchino Natoli, Francesca De Santa, Iros Barozzi, Flore Mietton, Serena Ghisletti, A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers PLoS Biology. ,vol. 8, pp. e1000384- ,(2010) , 10.1371/JOURNAL.PBIO.1000384
Cory Y McLean, Dave Bristor, Michael Hiller, Shoa L Clarke, Bruce T Schaar, Craig B Lowe, Aaron M Wenger, Gill Bejerano, GREAT improves functional interpretation of cis-regulatory regions Nature Biotechnology. ,vol. 28, pp. 495- 501 ,(2010) , 10.1038/NBT.1630
Gioacchino Natoli, Maintaining cell identity through global control of genomic organization Immunity. ,vol. 33, pp. 12- 24 ,(2010) , 10.1016/J.IMMUNI.2010.07.006
M. P. Creyghton, A. W. Cheng, G. G. Welstead, T. Kooistra, B. W. Carey, E. J. Steine, J. Hanna, M. A. Lodato, G. M. Frampton, P. A. Sharp, L. A. Boyer, R. A. Young, R. Jaenisch, Histone H3K27ac separates active from poised enhancers and predicts developmental state Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 21931- 21936 ,(2010) , 10.1073/PNAS.1016071107
Xi Chen, Han Xu, Ping Yuan, Fang Fang, Mikael Huss, Vinsensius B. Vega, Eleanor Wong, Yuriy L. Orlov, Weiwei Zhang, Jianming Jiang, Yuin-Han Loh, Hock Chuan Yeo, Zhen Xuan Yeo, Vipin Narang, Kunde Ramamoorthy Govindarajan, Bernard Leong, Atif Shahab, Yijun Ruan, Guillaume Bourque, Wing-Kin Sung, Neil D. Clarke, Chia-Lin Wei, Huck-Hui Ng, Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells Cell. ,vol. 133, pp. 1106- 1117 ,(2008) , 10.1016/J.CELL.2008.04.043
Taro Kawai, Shizuo Akira, Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity Immunity. ,vol. 34, pp. 637- 650 ,(2011) , 10.1016/J.IMMUNI.2011.05.006
Dong Wang, Ivan Garcia-Bassets, Chris Benner, Wenbo Li, Xue Su, Yiming Zhou, Jinsong Qiu, Wen Liu, Minna U. Kaikkonen, Kenneth A. Ohgi, Christopher K. Glass, Michael G. Rosenfeld, Xiang-Dong Fu, Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA Nature. ,vol. 474, pp. 390- 394 ,(2011) , 10.1038/NATURE10006
Simon C. Biddie, Sam John, Pete J. Sabo, Robert E. Thurman, Thomas A. Johnson, R. Louis Schiltz, Tina B. Miranda, Myong-Hee Sung, Saskia Trump, Stafford L. Lightman, Charles Vinson, John A. Stamatoyannopoulos, Gordon L. Hager, Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding Molecular Cell. ,vol. 43, pp. 145- 155 ,(2011) , 10.1016/J.MOLCEL.2011.06.016