Serotonin1A receptor autoradiography during alcohol-withdrawal kindling.
作者： J. Ulrichsen , Bjarke Ebert , Steven Haugbøl , B. Bech , Christian Holkmann Olsen
关键词: Internal medicine 、 Anesthesia 、 Entorhinal cortex 、 First episode 、 Endocrinology 、 Diazepam 、 Medicine 、 Ethanol 、 5-HT1A receptor 、 Kindling 、 Alcohol dependence 、 Hippocampus
摘要: A series of autoradiography experiments were conducted in order to test the theory that serotonin (5-HT) receptor subtype 5-HT1a is involved alcohol-withdrawal kindled convulsive behaviour. Alcohol-withdrawal kindling was performed by subjecting male Wistar rats multiple episodes consisting 2 days alcohol intoxication and 5 withdrawal. In first episode led focal downregulation [3H]-8-hydroxy-2-(di-n-propylamino)tetralin ([3H]-8-OH-DPAT) binding sites septum subregions frontal cortex, hippocampus, entorhinal cortex. This alcohol-induced response blunted both animals exposed repeated dependence which previous withdrawal reactions blocked diazepam administration. paradoxical upregulation [3H]-8-OH-DPAT found cortex control fed isocalorically with subsequently intoxication. It concluded alterations induced regulation after not caused processes per se, but due specific non-specific effects.
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sci-hub.se 参考文章(28)
R. Hemmingsen, A. G. Chapman, Cerebral Metabolic State During the Ethanol Withdrawal Reaction in the Rat Journal of Neurochemistry. ,vol. 34, pp. 1561- 1566 ,(1980) , 10.1111/J.1471-4159.1980.TB11244.X
Yuji Wada, Mitsuhiko Nakamura, Hidehiro Hasegawa, Nariyoshi Yamaguchi, Intra-hippocampal injection of 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats Neuroscience Letters. ,vol. 159, pp. 179- 182 ,(1993) , 10.1016/0304-3940(93)90828-9
David LeMarquand, Robert O. Pihl, Chawki Benkelfat, Serotonin and alcohol intake, abuse, and dependence: Clinical evidence Biological Psychiatry. ,vol. 36, pp. 326- 337 ,(1994) , 10.1016/0006-3223(94)90630-0
Susan R.B. Weiss, Robert M. Post, Francis Szele, Ruth Woodward, Jay Nierenberg, Chronic carbamazepine inhibits the development of local anesthetic seizures kindled by cocaine and lidocaine. Brain Research. ,vol. 497, pp. 72- 79 ,(1989) , 10.1016/0006-8993(89)90971-2
Edward Majchrowicz, Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacology. ,vol. 43, pp. 245- 254 ,(1975) , 10.1007/BF00429258
Edward Majchrowicz, Walter A. Hunt, Temporal relationship of the induction of tolerance and physical dependence after continuous intoxication with maximum tolerable doses of ethanol in rats. Psychopharmacology. ,vol. 50, pp. 107- 112 ,(1976) , 10.1007/BF00430477
Yuji Wada, Mitsuhiko Nakamura, Hidehiro Hasegawa, Nariyoshi Yamaguchi, Role of serotonin receptor subtype in seizures kindled from the feline hippocampus Neuroscience Letters. ,vol. 141, pp. 21- 24 ,(1992) , 10.1016/0304-3940(92)90325-2
G. CURZON, Serotonin and Appetite Annals of the New York Academy of Sciences. ,vol. 600, pp. 521- 530 ,(1990) , 10.1111/J.1749-6632.1990.TB16907.X
J. Ulrichsen, B. Bech, P. Allerup, R. Hemmingsen, Diazepam prevents progression of kindled alcohol withdrawal behaviour. Psychopharmacology. ,vol. 121, pp. 451- 460 ,(1995) , 10.1007/BF02246493
Martha E. Brown, Raymond F. Anton, Robert Malcolm, James C. Ballenger, Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis. Biological Psychiatry. ,vol. 23, pp. 507- 514 ,(1988) , 10.1016/0006-3223(88)90023-6