Regimen-related toxicity in patients undergoing bone marrow transplantation.

摘要: Bone marrow transplantation is associated with significant morbidity and mortality, some of which due to high-dose chemoradiotherapy. In order quantitate toxicity that was felt be the preparative regimen (termed regimen-related [RRT]), a system developed in toxicities were graded from 0 (none) 4 (fatal). One hundred ninety-five patients who underwent for leukemia studied retrospectively determine whether clinically influenced by other factors such as disease status, graft-versus-host (GVHD) prophylaxis, allogenicity. All grade I at least one organ, 30 grades III-IV (life-threatening or fatal) RRT. RRT more common relapsed v remission (P = .04), those receiving 15.75 Gy total body irradiation (TBI) 12.0 TBI .028), allogeneic autologous .0029). Autologous recipients did not develop this study. A multivariate analysis controlling grafting showed dose only statistically predictor Those III unlikely survive 100 days transplant, though all deaths could attributed Patients II three organs likely die within than developing two less .0027). This generally able distinguish observed recipients.