Addenbrooke’s Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson’s Disease

摘要: Objective. The main aim of this study was to verify the sensitivity and specificity Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) PD mild cognitive impairment (PD-MCI) PD-MCI dementia (PD-D). We also evaluated how ACE-R correlates neuropsychological tests PD. Methods. examined three age-matched groups patients diagnosed according Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, PD-D. ROC analysis used establish specific cut-off scores its domains. Correlation analyses were performed subtests relevant tests. Results. Statistically significant differences demonstrated global subscores, except language domain. score 88.5 points discriminated best PD-NC (sensitivity 0.68, 0.91); 82.5 distinguished PD-D 0.70, 0.73). verbal fluency domain discrimination (cut-off 11.5; 0.73) while orientation/attention subscore 15.5; 0.90, 0.97). for correlated interest.