Induction of Pulmonary Edema and Emphysema in Cattle and Goats with 3-Methylindole
作者： J. R. Carlson , M. T. Yokoyama , E. O. Dickinson
DOI: 10.1126/SCIENCE.176.4032.298
关键词: Interstitial pulmonary edema 、 Metabolite 、 Ruminal fermentation 、 Pharmacology 、 Tryptophan 、 In vitro 、 Rumen 、 Pulmonary disease 、 Pulmonary edema 、 Chemistry
摘要: Microorganisms from rumen converted L-tryptophan and indoleacetic acid to 3-methylindole in vitro. Oral doses of caused interstitial pulmonary edema emphysema cattle goats. Intravenous infusion this metabolite also induced disease cattle. These results demonstrate than an end product ruminal fermentation tryptophan can induce acute
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