Focal Adhesion Kinase: A Key Mediator of Transforming Growth Factor Beta Signaling in Fibroblasts
作者： Andrew Leask
关键词: Cytokine 、 Signal transduction 、 Focal adhesion 、 Transforming growth factor 、 Mediator 、 Cancer research 、 Medicine 、 Pathology 、 Myofibroblast 、 Transforming growth factor beta 、 Fibrosis
摘要: Significance: There is no effective drug therapy for scarring and fibrotic disease. The cytokine transforming growth factor beta (TGF-β) promotes tissue repair, but its excessive action can lead to over exuberant However, owing the multifunctional nature of TGF-β, broad targeting canonical Smad–TGF-β signaling pathway in vivo likely have unintended, deleterious consequences. Recent Advances: (1) myofibroblast essential cell type that mediates repair fibrosis. (2) TGF-β an contributor differentiation activity. (3) selectively fibrosis via noncanonical focal adhesion kinase (FAK) pathway; FAK differentiation, hence may represent a novel intervention point drugs treating Critical Issues: Excessive (e.g., hypertrophic scars, keloids, scleroderma) characterized by enhanced major cl...
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