Vitamin B12 and health.
作者： Milly Ryan-Harshman , Walid Aldoori
DOI:
关键词: Medicine 、 Cancer 、 Homocysteine levels 、 Nutritional genomics 、 Folic acid 、 Endocrinology 、 Disease 、 Mental health 、 Health benefits 、 Bioinformatics 、 Internal medicine 、 Vitamin B12
摘要: OBJECTIVE To review recent evidence that suggests vitamin B12 is associated with risk reduction for some chronic diseases and birth defects. QUALITY OF EVIDENCE A MEDLINE search from 1999 to 2007 was performed using the key word . The most relevant articles (129) dealt cardiovascular disease, cancer, mental health, outcomes; studies presented level II evidence. MAIN MESSAGE Vitamin might confer health benefits; however, such benefits are difficult ascertain because of complementary functions folic acid. lower high homocysteine levels below a threshold achieved by acid alone. Furthermore, interactions between nutritional environment genotype have an important influence on B12, disease risk, neural tube CONCLUSION help protect against defects, but more research, particularly in area genomics, needed determine how augment Some consideration should be given potential value fortifying foods addition current mandatory fortification grains.
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