Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells.

摘要: LPS injection into normal mice does not induce liver injury, while the same treatment of Propionibacterium acnes-primed induces severe indicating that P. acnes renders susceptible to LPS. Since IFN-gamma sensitizes macrophages LPS, we investigated mechanism induction and activation IFN-gamma-producing (type 1) T cells by acnes. Twenty percent lymphocytes C57BL/6 are CD4+ NK1.1+ promptly produce IL-4 in response anti-CD3 vitro. However, diminished these lymphocytes. Therefore, from showed reduced production. Furthermore, induced CD4- type 1 liver. Isolated acnes-elicited Kupffer produced IL-12 a lesser degree IL-18 Injection anti-IL-12 Ab totally abrogated actions acnes, anti-IL-18 caused only partial abrogation. Thus, administration cells, but (approximately 1,000 ng) dose dependently cells. In contrast, failed, although much larger (10,000 or with suboptimal doses (1-100 dose-dependent manner. highly