Modes of administration of antibiotics for symptomatic severe urinary tract infections

摘要: Background Urinary tract infection (UTI), worldwide, is a major source of disease in children and adults. As it may have long-term consequences such as kidney failure hypertension, important to treat patients with UTI adequately. Although standard management severe usually means intravenous (IV) therapy, at least initially, there are studies showing that oral therapy also be effective. Objectives To assess whether the mode administration antibiotic for has an effect on cure rate, reinfection rate scarring. Search strategy The Cochrane Renal Group's specialised register, Central Register Controlled Trials (CENTRAL, Library), MEDLINE EMBASE were searched. No language restriction was applied. Reference lists relevant articles reviews checked additional authors articles/abstracts contacted further information. Date last search: July 2007. Selection criteria All randomised controlled trials (RCTs) comparing different modes application (children adults) considered. Data collection analysis Study quality assessed data extracted. Statistical analyses performed using random effects model results expressed relative risk (RR) dichotomous outcomes or mean difference (WMD) continuous 95% confidence intervals (CI). Main Fifteen RCTs (1743 patients) included. Studies compared versus parenteral treatment (1), switch (initial intramuscular (IM) followed by therapy) (5), (6) single dose (1) (3). There variety short-term outcomes, but no pooled showed significant differences. Most included small though few combination meta-analysis. Authors' conclusions evidence suggesting less effective than initial therapy. this review suggest does not determine therapeutic success.