Neutrophil-mediated lung localization of bacteria: a mechanism for pulmonary injury.

摘要: The reticuloendothelial system (RES) is thought to ensure organ integrity following trauma, burn, and sepsis by removing potentially embolic particulate matter blood-borne bacteria from the circulation. Blockade of RES with foreign colloids known result in a consumptive depletion opsonic fibronectin, which modulates function, an increase lung localization test particles. We investigated role neutrophils as contributing factor increased after blockade. RE blockade induced gelatin-coated colloid particle injection resulted acute (15-minute) number 51Cr-labeled localized lung, return control levels at 60 minutes Fibronectin administration significant (P less than 0.05) prolonged retention up 2 hours A parallel heat-killed 14C-labeled Pseudomonas aeruginosa colloid-induced was observed, fibronectin further lung. Experimentally neutropenia abrogated effect on bacteria. It concluded that load results simultaneous neutrophil margination both contribute mechanism for neutrophil-mediated pulmonary injury related dysfunction trauma proposed.