Dosimetric assessment of radiolabelled lipiodol as a potential therapeutic agent in colorectal liver metastases using combined CT and SPECT.

摘要: Lipiodol has previously been used as an agent for targeted radiotherapy by selective retention in primary hepatic tumours following direct arterial infusion. We have considered the potential dosimetry of 131I-labelled lipiodol treating colorectal liver metastases. Fifteen patients with multiple metastases underwent angiography when 5 ml labelled 40 MBq 131I were infused. All planar scintigraphy abdomen and thorax, single photon emission computed tomography (SPECT) whole body counting on at least two occasions injection. Computed tomographic (CT) images also taken typically 7 days postinjection. The was found to deposit periphery less than 10 cm diameter. In one patient a metastasis diameter greater 15 failed infuse. lobe containing not successfully Overlay CT SPECT confirmed concentration Quantification indicated that between 55 100% (median 86%) injected activity retained injection, tumour ratios dose delivered ranged from 1.21:1 4.7:1 3.1:1). Tumour does 11.8 43.3 mGy MBq-1 injected. Dose lungs 0 46% 16%). treatment radiotherapy.