Mechanisms of Antibiotics: How Do They Really Work

摘要:  Summary In the absence of immunological challenges, production animals can grow to their full genetic potential. The greatest (immunological) costs for growth are associated with inflammation, because inflammation causes a reduced appetite, muscle catabolism, and predisposes infections. Whereas most familiar systemic local intestinal is more relevant in animals. Also called metabolic (MI), it normal post-prandial reaction, level which determined by energy value feed. Hence, regulation MI be overwhelmed, leading growth. This imbalance remedied feeding anti-inflammatory compounds. fact, antibiotics have been used as very cost effective promoters health examples latter. For years, promoting activity was attributed antibiotic properties, highly unlikely sub therapeutic concentrations were bacterial resistance wide spread. Antibiotics antimicrobial (AGP) work direct inhibition MI, do non-antibiotic compounds like acetylsalicylic acid, polyphenols, certain fatty acids. Alternatives AGP should therefore compounds, makes argument inducing irrelevant. preferably not registered drugs. Plants contain host candidates. Pre-selection performed using simple vitro (anti-) inflammatory assays, followed vivo trials. Selected successful at this moment, will help maintain profitability while reducing reliance on antibiotics.