Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model of Alzheimer's Disease.
作者： Lucian Hritcu , Dragos Lucian Gorgan , Marius Mihasan , Razvan Stefan Boiangiu , Bogdan Alexandru Stache
关键词: Pharmacology 、 Cotinine 、 Nicotine 、 Acetylcholinesterase 、 Nicotinic agonist 、 Zebrafish 、 Aché 、 Oxidative stress 、 Chemistry 、 Anxiolytic
摘要: Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess cognitive-improving abilities antioxidant properties in different rodent models of Alzheimer's disease (AD), eluding the side-effects nicotine (NIC), parent molecule. In current study, we evaluated impact COT 6HLN on memory deterioration, anxiety, oxidative stress scopolamine (SCOP)-induced zebrafish model AD. For this, were acutely administered by immersion to treated with SCOP before testing. The performances assessed Y-maze object discrimination (NOR) tasks, while anxiety-like behavior was novel tank diving test (NTT). acetylcholinesterase (AChE) activity measured from brain samples. RT-qPCR analysis used evaluate npy, egr1, bdnf, nrf2a gene expression. Our data indicated both attenuated SCOP-induced impairment reduced AChE zebrafish. Finally, increased Therefore, could be as tools for improving AD conditions.
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