Nucleotide interactions with 5-HT1A binding sites directly labeled by [3H]-8-hydroxy-2-(di)-n-propylamino) tetralin ([3H]-8-OH-DPAT)
作者： Jerry R. Schlegel , Stephen J. Peroutka
DOI: 10.1016/0006-2952(86)90725-2
关键词: Nucleotide 、 Tetralin 、 8-Hydroxy-2-(di-n-propylamino)tetralin 、 Stereochemistry 、 Non-competitive inhibition 、 Chemistry 、 GTP' 、 8-OH-DPAT 、 Binding site 、 Biochemistry 、 Pharmacology
摘要: Abstract Nucleotide interactions were examined at 5-hydroxytryptamine1A (5-HT1A) binding sites labeled by [3H]-8-hydroxy-2-(di)-n-propylamino)tetralin (8-OH-DPAT). At a 10−4M concentration, GTP and GDP decreased specific of 0.4 nM [ 3 M]-8-OH-DPAT to 47 ± 4 61 1% control values respectively. This nucleotide effect was significantly greater (P
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