Prevention of type 2 diabetes

摘要: Type 2 diabetes is increasing worldwide in epidemic proportions. Its associated morbidity and mortality imposing a major burden on the health care system. Based better understanding of pathophysiology glucose intolerance, clinical trials prevention have been performed. It has now demonstrated that diet exercise, metformin, acarbose, troglitazone can prevent or at least delay development subjects with impaired tolerance (IGT). generally accepted insulin resistance β-cell dysfunction are factors involved diabetes. The relative contribution versus pathogenesis aroused much debate. These two processes should be studied relation to one another: their relationship best described as hyperbolic nature. When this taken into consideration, it becomes evident risk developing type before they develop intolerance. Insulin may mostly explained by presence obesity accelerate progression propensity failure. By time hyperglycemia occurs, impairment both sensitivity secretion present. There still few data from we do suggest most interventions an effect resistance. reducing resistance, protect preserve function. No intervention yet shown any direct