Effects of topical application of UF-021, a novel prostaglandin-related compound, on aqueous humor dynamics in rabbit.
作者： Shoji N , Masuda K , Oshika T , Araie M , Sakurai M
DOI:
关键词: Lagomorpha 、 Ocular hypertension 、 Albumin 、 Fluorescein 、 Pharmacology 、 Surgery 、 Chemistry 、 Prostaglandin 、 Permeability (electromagnetism) 、 Intraocular pressure 、 Unoprostone
摘要: The mechanism underlying the intraocular pressure (IOP) lowering effect of a novel prostaglandin-related compound, (+)-isopropyl Z-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)-cyclopentyl]hept-5 -enoate (UF-021), and influence this new hypotensive agent on permeability blood-aqueous barrier (BAB) were studied in albino rabbits. A single instillation 0.06% UF-021 significantly lowered IOP with peak reduction 5.2 mmHg without changing aqueous flow rate. Uveoscleral outflow facility to general blood circulation both increased. BAB evaluated fluorescein isothiocyanate-labeled rabbit albumin (FITC-RA) showed approximately sixfold increase after UF-021, which suggested drug-induced compromise BAB.
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