Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

作者: Motoko Koyama , Rachel D Kuns , Stuart D Olver , Neil C Raffelt , Yana A Wilson

DOI: 10.1038/NM.2597

关键词: T cellGastrointestinal tractCytokineMajor histocompatibility complexAntigen-presenting cellLymphatic systemBiologyMHC class IIImmunologyTransplantationGeneral Biochemistry, Genetics and Molecular BiologyGeneral Medicine

摘要: … Third, recipient B cells and macrophages are not required and actually suppress aGVHD 10,11,… : FITC-conjugated antibodies to CD45.1, CD45.2, MHC class II (IA/IE) and IgG2a isotype; …

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