Gentamicin-loaded bioresorbable films for prevention of bacterial infections associated with orthopedic implants.

摘要: Adhesion of bacteria to biomaterials and the ability many microorganisms form biofilms on foreign bodies are well-established as major contributors pathogenesis implant-associated infections. Treatment bone infection remains problematic, due difficulty systemically administered antibiotics locally penetrate bone. The current research addresses this issue by focusing development study novel gentamicin-loaded bioresorbable films designed serve "coatings" for fracture fixation devices prevent Poly(L-lactic acid) poly (D,L-lactic-co-glycolic containing gentamicin were developed through solution processing. effects polymer type, drug content, processing conditions release profile studied with respect film morphology. examined generally exhibited a burst effect followed moderate approximately constant rate release. contents in surrounding medium exceeded required minimal effective concentration. Various concentrations that released from time efficacy against bacterial species known be involved orthopedic systems can applied surface any metallic or polymeric device, may therefore comprise significant contribution field implants.