Selective laser melting-produced porous titanium scaffolds regenerate bone in critical size cortical bone defects.

摘要: Porous titanium scaffolds have good mechanical properties that make them an interesting bone substitute material for large defects. These can be produced with selective laser melting, which has the advantage of tailoring structure's architecture. Reducing strut size reduces stiffness structure and may a positive effect on formation. Two struts 120-µm (titanium-120) or 230-µm (titanium-230) were studied in load-bearing critical femoral defect rats. The was stabilized internal plate treated titanium-120, titanium-230, left empty. In vivo micro-CT scans at 4, 8, 12 weeks showed more defects scaffolds. Finally, 18.4 ± 7.1 mm3 (titanium-120, p = 0.015) 18.7 ± 8.0 mm3 (titanium-230, p = 0.012) formed those defects, significantly than empty (5.8 ± 5.1 mm3). Bending tests excised femurs after fusion strength reached 62% 45% intact contralateral femurs, but there no significant difference between two This study addition to adequate support, porous facilitate formation, results high integrity © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 792–799, 2013