WNT signalling in the immune system: WNT is spreading its wings.

摘要: WNT proteins are secreted morphogens that required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species organs. In blood immune cells, signalling controls progenitor cells might also affect decisions stem cells. Recent studies indicate regulate effector T-cell development, regulatory activation dendritic-cell maturation. seems to function a universal mechanism leukocytes establish pool undifferentiated further selection, effector-cell maturation terminal differentiation. is therefore subject strict molecular control, dysregulated implicated development haematological malignancies.