Amplification of genes encoding KIT, PDGFRα and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme

摘要: KIT, platelet-derived growth factor receptors (PDGFRs) and vascular endothelial (VEGFRs) are important clinical targets for tyrosine kinase inhibitors. The frequency of KIT VEGFR2 amplification in glioblastomas is not known, few data available any other human tumour type. We investigated 43 primary VEGFR2, PDGFRA EGFR using fluorescence situ hybridization. was amplified 47% 39% the glioblastomas, respectively, 29%. Thirty-five (81%) tumours had either or amplification. amplifications were strongly associated (p < 0.0001 each pairwise comparison), suggesting co-amplification, whereas no significant association found with four secondary arising from pre-existing lower grade astrocytic but none No mutations detected denaturing high-performance liquid chromatography exons 9, 11, 13 17, 12 18, 19 21. Glioblastomas PDGFR similar outcome to glioblastomas. conclude that commonly glioblastoma they may also be glioblastoma. Amplified kinases potential inhibitor therapy.