Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech.

摘要: Apraxia of speech (AOS) is a motor disorder characterized by slow speaking rate, abnormal prosody and distorted sound substitutions, additions, repetitions prolongations, sometimes accompanied groping, trial error articulatory movements. Although AOS frequently subsumed under the heading aphasia, indeed most often co-occurs with it can be predominant or even sole manifestation degenerative neurological disease. In this study we determine whether clinical classifications aphasia correlated pathological diagnoses specific biochemical anatomical structural abnormalities. Seventeen cases initial were re-classified independently two speech-language pathologists--blinded to findings--into one five operationally defined categories AOS. Pathological in 17 progressive supranuclear palsy 6, corticobasal degeneration 5, frontotemporal lobar ubiquitin-only-immunoreactive changes 5 Pick's disease 1. Magnetic resonance imaging analysis using voxel-based morphometry (VBM), single photon emission tomography completed, blinded diagnoses, clinicoimaging clinicopathological associations then sought. Interjudge classification reliability was 87% (kappa = 0.8) for all evaluations. Eleven had evidence AOS, which (100%) diagnosis underlying tau biochemistry, while other six without did not have biochemistry (P 0.001). A majority more than yearly evaluation, demonstrating evolution language syndromes, as well signs. VBM revealed premotor supplemental cortices main cortical regions associated anterior peri-sylvian region non-fluent aphasia. Refining aphasias may necessary improve our understanding relationships among behavioural, correlations.