Side reactions in peptide synthesis. V.A reexamination of the mixed anhydride method.
作者： Miklos Bodanszky , John C. Tolle
DOI: 10.1111/J.1399-3011.1977.TB02811.X
关键词: Peptide sequence 、 Chemistry 、 Valine 、 Amino acid 、 Side reaction 、 Isoleucine 、 Peptide synthesis 、 Stereochemistry 、 Acylation
摘要: Acylation of amino acid beta-naphthylamides with protected (Boc) acidisobutylcarbonic mixed anhydrides resulted in each case the formation some undesired by-product: an isobutyloxycarbonylamino beta-naphthylamide. The amount this second acylation product was particularly high, hindered acids valine and isoleucine as carboxyl-components. nature component had no major influence on extent side reaction.
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