Kinetic Isotope Effects in Proton-Transfer Reactions

摘要: Kinetic isotope effects in general have now become an everyday tool of the mechanistic organic chemist, and this is particularly true hydrogen effects, partly because involved so many reactions, such are much larger for than isotopes heavier atoms. It interesting to note that rate differences between deuterium compounds sometimes large use has been proposed as a practical expedient slowing down harmful e.g., deterioration lubricants by oxidation.1 Since publication first edition book number books review articles appeared on subject kinetic effects.2–5 The present chapter will therefore be confined almost entirely proton-transfer though some reference made closely allied problem reactions involving transfer atoms, especially connection with tunnel effect. On other hand, no increasing secondary obtaining information about neighbouring group participation, solvolytic reactions,6 since these do not normally involve proton transfers. Even field only selection available material covered.