Metabolism of Organophosphorus Anticholinesterase Agents

摘要: The growth of the chemical industry has brought a large number new compounds into common use. Technological developments are sometimes attended by toxicological problems, study which in certain cases led to significant advances biochemical knowledge. An example this been provided development group organic derivatives phosphoric acid, some among most poisonous substances known. Many these compounds, originally developed as pesticides, also useful tools physiology and biochemistry may provide drugs for medicine. A organophosphorus have considered potential warfare agents, other related finding uses industries Balls Jansen (1953) pointed out that any extensively toxic substance is be suspected priori being an inhibitor vitally important enzyme system, physiological process characteristic was found inhibition cholinesterases (ChE’s).