A miniaturised analytical protocol for highly sensitive determination of bisphenol A in bottled drinking water

摘要: This paper proposes a novel, fast, reliable and miniaturised analytical protocol for highly sensitive determination of bisphenol A (BPA) in bottled drinking water. hybrid approach involves lucid expeditious combination micro-extraction packed syringe (MEPS) with high performance liquid chromatography coupled to an ultra-violet detector (HPLC-UV). The method was developed, optimised validated the BPA commercial water remarkable sensitivity picogram quantities (ppt level). important parameters MEPS procedure affecting extraction efficiency were optimized 50 cycles draw–eject sample speed 10 μl s−1 gave maximum peak area, time 0.998). Precision studies showed % RSD values less than 2% all selected concentrations. percentage recoveries range 97.50–97.57. limit detection (LOD) quantification (LOQ) 0.0416 pg ml−1 0.1248 BPA, respectively. proposed successfully applied quantitative analysis real beverage samples level 5.40 14.22 ml−1, acceptable (%) 3–9 is suitable routine monitoring water, regulatory purposes. Furthermore, this should also allow easy expansion quality records different related compounds like octyl nonyl phenol as well S F